Efficacy of cardiac contractility modulation confirmed
نویسندگان
چکیده
منابع مشابه
Cardiac contractility modulation therapy: Are there superresponders?
Introduction Heart failure (HF) is a common cardiovascular disease, and it is associated with high morbidity and mortality despite advances in medical and device-related management. Patients with HF with low left ventricular ejection fraction (LVEF) and narrow QRS complexes represent a special challenge, as they are not candidates for cardiac resynchronization therapy (CRT). These patients may ...
متن کاملModulation of cardiac contractility. A potential treatment of heart failure?
During the last 10 years, electrical treatment of heart failure (HF) has become more and more popular. Cardiac resynchronization therapy (CRT), alone or combined with defibrillation, has been confirmed to be effective in patients with moderate or severe HF and ventricular dyssynchrony, manifest as a QRS duration .120 ms, though its effectiveness has not been confirmed in patients presenting wit...
متن کاملModulation of cardiac contractility by the phospholamban/SERCA2a regulatome.
Heart disease remains the leading cause of death and disability in the Western world. Current therapies aim at treating the symptoms rather than the subcellular mechanisms, underlying the etiology and pathological remodeling in heart failure. A universal characteristic, contributing to the decreased contractile performance in human and experimental failing hearts, is impaired calcium sequestrat...
متن کاملCardiac contractility modulation in patients with advanced heart failure.
Cardiac contractility modulation (CCM) is a novel device-based therapy for heart failure that involves applying electrical signals during the absolute refractory period of the myocardial action potential. This therapy has been shown to augment the strength of left ventricular contraction independent of myocardial oxygen consumption in animal models as well as human studies of patients with hear...
متن کاملSubgroup analysis of a randomized controlled trial evaluating the safety and efficacy of cardiac contractility modulation in advanced heart failure.
BACKGROUND Cardiac contractility modulation (CCM) signals are nonexcitatory electrical signals delivered during the absolute refractory period intended to improve contraction. We previously tested the safety and efficacy of CCM in 428 NYHA functional class III/IV heart failure patients with EF ≤35% and narrow QRS randomized to optimal medical treatment (OMT) plus CCM (n = 215) versus OMT alone ...
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ژورنال
عنوان ژورنال: Nature Reviews Cardiology
سال: 2018
ISSN: 1759-5002,1759-5010
DOI: 10.1038/s41569-018-0038-4